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Question

Answered

Question    
  1    
  (12    
  marks)
Use    
  this    
  extract    
  taken    
  from    
  the    
  article,    
  “Goji    
   berries    
  prevent    
  macular    
  degeneration,”    
  (appeared    
  in    
   Healthy    
  Foods,    
  Healthy    
  Bodies    
  on    
  January    
  21,    
  2016)    
  to    
  answer    
  the    
  questions    
   that    
  follow:    
   Goji    
  berries    
  (Lycium    
  barbarum    
  L.)    
  are    
  thought    
  to    
  benefit    
  vision    
  because    
  of    
   their    
  high    
  antioxidant    
  content.    
  The    
  macular,    
  an    
  important    
  pigmented    
  area    
   near    
  the    
  center    
  of    
  the    
  retina    
  of    
  the    
  eye,    
  is    
  responsible    
  for    
  central    
  vision.    
  In    
   the    
  elderly,    
  macular-­â€degeneration    
  is    
  a    
  primary    
  cause    
  of    
  failing    
  eye-­â€sight.    
  A    
   recent    
  study    
  by    
  scientists    
  at    
  the    
  Nestlé    
  Research    
  Centre,    
  Switzerland    
  and    
   Shanghai    
  Jiao    
  Tong    
  University    
  School    
  of    
  Medicine    
  investigated    
  the    
  effects    
  of    
   daily    
  supplementation    
  of    
  a    
  mixture    
  of    
  goji    
  berries    
  and    
  lacto-­â€wolfberry    
  on    
   macular    
  characteristics    
  of    
  the    
  eyes    
  in    
  elderly    
  subjects.    
   A    
  double-­â€blind,    
  randomised,    
  placebo-­â€controlled    
  trial    
  was    
  conducted    
  with    
   150    
  healthy    
  elderly    
  subjects    
  aged    
  65    
  to    
  70    
  years.    
  Randomisation    
  was    
   stratified    
  by    
  gender.    
  For    
  a    
  period    
  of    
  90    
  days,    
  75    
  randomly    
  selected    
   participants    
  were    
  assigned    
  to    
  receive    
  the    
  mixture    
  of    
  berries    
  in    
  a    
  powdered    
   form    
  mixed    
  in    
  with    
  their    
  daily    
  lunch-­â€time    
  soup,    
  while    
  the    
  remaining    
  75    
   participants    
  were    
  given    
  a    
  powdered    
  mixture    
  that    
  did    
  not    
  contain    
  the    
  active    
   ingredients    
  with    
  their    
  usual    
  soup.    
  Before    
  and    
  after    
  the    
  90    
  days    
  of    
  the    
  trial,    
   the    
  elderly    
  subjects    
  underwent    
  eye    
  examinations    
  to    
  assess    
  pigmentation    
   and    
  the    
  presence    
  of    
  age-­â€related    
  macular    
  degeneration.    
   It    
  was    
  found    
  that    
  the    
  daily    
  dietary    
  supplementation    
  with    
  goji    
  berry    
  and    
   lacto-­â€    
  wolfberry    
  for    
  90    
  days    
  increases    
  antioxidant    
  levels    
  as    
  well    
  as    
  protects    
   from    
  hypopigmentation    
  in    
  the    
  macula    
  of    
  elderly    
  subjects,    
  reducing    
  the    
  risk    
   of    
  macular-­â€    
  degeneration.    
  However,    
  the    
  mechanism    
  of    
  action    
  is    
  unclear.    
   .   (a)    
      
  (2    
  marks)    
  Is    
  this    
  particular    
  study    
  that    
  was    
  cited    
  in    
  the    
  article    
   observational    
  or    
  experimental?    
  In    
  less    
  than    
  50    
  words    
  clearly    
  explain    
   your    
  choice    
  based    
  on    
  the    
  extract    
  given    
  above.    
  â€¨
.   (b)    
      
  (2    
  marks)    
  Identify    
  the    
  variable(s)    
  of    
  interest.    
  â€¨ .   (c)    
      
  (4    
  marks)    
  Explain    
  what    
  is    
  meant    
  by    
  ‘double-­â€blind,    
  randomised,    
  placebo    
   controlled    
  trial’    
  in    
  the    
  â€¨context    
  of    
  the    
  study.    
  â€¨ .   (d)    
      
  (4    
  marks)    
  Explain    
  what    
  is    
  meant    
  by    
  ‘Randomisation    
  was    
  stratified    
  by    
   gender’.    
  Why    
  might    
  the    
  researchers    
  in    
  this    
  study    
  decide    
  to    
  ‘stratify    
  by    
   gender’?    
  â€¨ Question    
  2    
  (18    
  marks)    
   High    
  total    
  cholesterol    
  was    
  the    
  second    
  greatest    
  attributor    
  to    
  the    
  total    
  burden    
   of    
  heart    
  disease    
  in    
  Australia,    
  according    
  to    
  the    
  Heart    
  Foundation.    
  Of    
  great    
   concern    
  is    
  the    
  number    
  of    
  younger    
  people    
  with    
  a    
  high    
  total    
  cholesterol    
  level.    
   In    
  fact,    
  25%    
  of    
  adults    
  aged    
  25-­â€34    
  years    
  have    
  a    
  higher    
  than    
  normal    
  total    
   cholesterol    
  level.    
   A    
  random    
  sample    
  of    
  12    
  people    
  between    
  the    
  ages    
  of    
  25    
  and    
  34    
  years    
  were    
   selected    
  from    
  the    
  Springfield    
  campus    
  to    
  have    
  their    
  total    
  cholesterol    
  level    
   checked.    
  The    
  variable    
  of    
  interest    
  is    
  the    
  number    
  of    
  people    
  between    
  the    
  ages    
   of    
  25    
  and    
  34    
  years    
  who    
  have    
  a    
  high    
  total    
  cholesterol    
  level.    
   Use    
  this    
  information    
  to    
  answer    
  the    
  following    
  questions:    
   .   (a)    
      
  (6    
  marks)    
  Suggest    
  an    
  appropriate    
  model    
  to    
  estimate    
  the    
  probabilities    
   of    
  the    
  number    
  of    
  people    
  between    
  the    
  ages    
  of    
  25    
  and    
  34    
  years    
  who    
   have    
  a    
  high    
  total    
  cholesterol    
  level    
  (1    
  mark).    
      What    
  are    
  the    
  parameters    
  of    
  this    
  model    
  for    
  this    
  context?    
  (1    
  mark)    
  â€¨    
     Explain    
  why    
  this    
  model    
  is    
  appropriate    
  by    
  discussing    
  the    
  important    
   distinguishing    
  â€¨features    
  of    
  the    
  model    
  (4    
  marks).    
  â€¨    
   .   (b)    
      
  (2    
  marks)    
  Using    
  the    
  model    
  from    
  part    
  (a),    
  estimate    
  the    
  probability    
  that,    
   in    
  the    
  randomly    
  selected    
  sample    
  of    
  12    
  people    
  from    
  Springfield    
  campus    
   aged    
  25    
  to    
  34    
  years,    
  3    
  or    
  less    
  will    
  have    
  a    
  high    
  total    
  cholesterol    
  level.    
  â€¨ .   (c)    
      
  (4    
  marks)    
  A    
  random    
  sample    
  of    
  120    
  people    
  aged    
  between    
  25    
  and    
  34    
 
years    
  have    
  been    
  selected    
  from    
  the    
  Toowoomba    
  campus    
  to    
  have    
  their    
   cholesterol    
  level    
  checked.    
  For    
  this    
  sample    
  of    
  120,    
  estimate    
  the    
  mean    
   and    
  standard    
  deviation    
  of    
  the    
  number    
  of    
  people    
  aged    
  25    
  to    
  34    
  years    
   who    
  have    
  a    
  high    
  total    
  cholesterol    
  level.    
  â€¨ .   (d)    
      
  (4    
  marks)    
  Determine    
  the    
  probability    
  that,    
  in    
  the    
  random    
  sample    
  of    
  120    
   people    
  (selected    
  in    
  part    
  (c)),    
  20    
  or    
  more    
  will    
  have    
  a    
  high    
  total    
   cholesterol    
  level.    
  â€¨ .   (e)    
      
  (2    
  marks)    
  State    
  and    
  check    
  any    
  assumptions,    
  conditions    
  or    
  rules    
  of    
   thumb    
  that    
  should    
  be    
  considered    
  before    
  performing    
  the    
  calculations    
   to    
  determine    
  the    
  probability    
  in    
  part    
  (d).    
  â€¨ Question    
  3    
  (14    
  marks)    
   This    
  question    
  uses    
  information    
  from    
  the    
  data    
  file    
  diabetes16.sav    
  found    
   under    
  the    
  Assignments    
  and    
  Datasets    
  link    
  on    
  the    
  StudyDesk    
  (also    
  see    
   diabetes.txt    
  for    
  more    
  details    
  about    
  the    
  health    
  study    
  and    
  the    
  variables    
   measured).    
  Make    
  sure    
  the    
  variable    
  view    
  in    
  SPSS    
  is    
  setup    
  correctly    
  with    
  all    
   ‘labels’    
  correctly    
  defined    
  (with    
  units),    
  all    
  ‘values’    
  assigned    
  correctly    
  for    
   categorical    
  variables    
  and    
  the    
  correct    
  ‘measure’    
  selected    
  for    
  all    
  variables.    
   As    
  a    
  researcher    
  seeking    
  to    
  gain    
  insights    
  into    
  the    
  variables    
  measured    
  in    
  this    
   study,    
  you    
  are    
  interested    
  in    
  ascertaining    
  if    
  there    
  is    
  a    
  relationship    
  between    
   gender    
  and    
  body    
  frame    
  (build)    
  of    
  African    
  American    
  people    
  living    
  in    
  Virginia.    
   .   (a)    
      
  (4    
  marks)    
  Using    
  SPSS,    
  produce    
  a    
  contingency    
  table    
  to    
  display    
  the    
   relationship    
  between    
  Gender    
  and    
  Body    
  Frame    
  for    
  participants    
  in    
  this    
   study.    
  The    
  title    
  for    
  this    
  table    
  should    
  reflect    
  the    
  table    
  contents    
  and    
  also    
   include    
  your    
  name.    
  (Note    
  that    
  a    
  table    
  title    
  should    
  appear    
  above    
  the    
   table).    
  You    
  can    
  copy    
  and    
  paste    
  this    
  table    
  straight    
  into    
  your    
   assignment;    
  just    
  ensure    
  you    
  have    
  a    
  meaningful    
  title.    
  â€¨

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