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Pleiotropy and Its Affect On Human Genetic Disorders

Referencing Styles : MLA | Pages : 1

Pleiotropy takes place in the human genetic system when one gene influences two or more than two seemingly unrelated phenotypic traits of the surrounding genes. Such a particular type of gene which exhibits multiple phenotypic related expression is called a pleiotropic gene. Mutation within a pleiotropic gene might have effects on several traits simultaneously, due to the coding based upon the gene for a specific product used by a group of cells or different targeted areas possess the same signaling function.

Pleiotropy can take place due to various different but potential holding overlapping mechanisms, such as the gene pleiotropy. Gene pleiotropy takes place when specific gene products have interaction with multiple proteins of other types or may catalyze multiple forms of reactions. Developing pleiotropy occurs when mutations have several multiple effects on the resultant phenotype. Selective pleiotropy occurs when the resultant phenotype has numerous effects upon the fitness of the human body, such as age and gender.

Effects of pleiotropy on Human Genetic disorder

On the basis of Mendel’s experiments, it might be imagined that all genes work towards a single characteristic, are present in pairs and have an effect upon some harmless aspect such as the appearance of any human. The human genetic disorder referred to as Marfan syndrome is caused due to the happening of mutation within one single gene. Yet, it has an effect upon many aspects of human growth and development such as height, vision and heart function. Such effects upon the human growth or in that case, the appearance of the human being is all due to the mutation within a single gene.

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