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Bacterial Nucleoid-associated Proteins

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Question:

Analyze the effect of various transcriptional regulatory proteins.

 

Answer:

An operon is a particular portion of genetic material that acts as a functioning unit and is composed of a cluster of genes that are controlled under a single promoter. In the process of transcription, there are two types of operons and those are, lac-operons or inducible operons and repressible operons (Dillon & Dorman, 2010).

A lac-operon is a unit composed of genetic material that is activated in the response to the presence of some particular chemicals.

Repressible operon is an operon, whose transcription reduces when a particular substance mainly the end products of any biosynthetic pathway is present.

The regulatory proteins are basically the product of the regulatory genes of an operon. An mRNA is produced by the regulatory genes of the operon that produces a repressor protein, which in turn binds to the operator site of the lac-operon. This lac repressor protein is also known as regulatory protein as it prevents the transcription of the structural genes by keeping away the RNA polymerase (Schleif, 2010).

 

References:

Dillon, S. C., & Dorman, C. J. (2010). Bacterial nucleoid-associated proteins, nucleoid structure and gene expression. Nature Reviews Microbiology, 8(3), 185-195.

Schleif, R. (2010). AraC protein, regulation of the l-arabinose operon in Escherichia coli, and the light switch mechanism of AraC action. FEMS microbiology reviews, 34(5), 779-796.

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