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Diabetes Receiving Intensive Insulin Therapy

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Question:

Describe about the Diabetes Receiving Intensive Insulin Therapy?
 
 

Answer:

The present research paper presents data on the quantitative effects of glycemic index on the postprandial glucose excursion (PPGE). The target population of the study is the children who are suffering from type 1 diabetes and as a result receive multiple injections a day. The research methods were based on continuous glucose monitoring of the standardized dose of insulin. There were twenty subjects and they were made to consume test breakfast that had equal amount of macronutrients and this meal was provided for four consecutive days. The PPGE was found to be much lower for the ones with lower glycemic index lunch as compared to the meal with high glycemic index. The conclusion drawn from the study was that the low glycemic index meals produced lower PPGE than the high glycemic index meals and this confirmed that preprandial ultra short acting insulin is the best or rather the therapy that is optimal for low glycemic index meal as it produced higher levels of postprandial blood glucose. Therefore the postprandial injection is not considered as a standard technique for management of low glycemic index.

 

Pros:

The statistical data corresponding to the monitoring of the glucose, was shown in a lucid manner with the help of graphs and charts.

The questionnaire was conducted by considering the ethical and legal aspects of the research design. The ethical approval was taken from the Hunter New England Human Research Ethics Committee and a written consent was also obtained.

The study was performed in a randomized control trial way. The sensur failures were subjected to repeated performance of tests, for accurate results.

Cons:

This is the first study to examine the effect on PPGE, of the changing glycemic index (in meals and thus, the results cannot be validated or used for future research.

The study was influenced by various factors like lack of standardization of fiber and the macronutrient content in the meal being provided

A limitation was that the more simple variations in glycemic index values may cause less significant changes in the PPGE levels

Another problem is the shape of the curve for the postprandial blood glucose may be different if fruit juice was substituted with the starchy food with same glycemic index. Therefore, more research and prior art is required to validate the results for applying them in future research and studies.

 

References:

Ryan et al. (2008). Influence of and Optimal Insulin Therapy for a Low–Glycemic Index Meal in Children With Type 1 Diabetes Receiving Intensive Insulin Therapy. Diabetes care. 31: 1485-1490
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