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Mr. Peter Woodland Case Study Analysis

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Questions:

1.Explain the terms Normocytic? Normochromic anemia, marked leucocytosis and marked thrombocytopenia.
 
2.Discuss about the Significance of the presence of numerous blast cells in Peter’s blood.
 
 

Answers:

1.Normocytic?normochromic anemia is a form of anemia where the average hemoglobin content and size of the red blood cell are within the acceptable limits. A microscopic test of the red blood cells shows them to be normal cells. However, in other cases, there are variations in the shape and size of the cells, which act to equalize each other forming a standard value. The condition is caused by unrelated illness, which includes inflammatory diseases, malignant illness, and chronic infections, which leads to a reduction in the concentration of iron in the blood (Petrella, Bagot, Delaunay & Muret, 2015).

Marked leukocytosis refers to the white blood cells of equal or greater than 80% established neutrophils and equal or greater than 25, 000/microL by a dissimilar count. A higher percentage of leucocytes can be attributed to the kind of drugs being taken by an individual, bacterial infections, or cancer. However, the degree of elevation of the leucocytes can be a clear indicator of the extent of infections (Palmer, Rozenberg & Machin, 2015).

Marked thrombocytopenia refers to a low platelet count, which can be described as medically significant. Patients with less than 50,000 platelets/ micro-liter are more likely to experience spontaneous bleeding while those whose platelet count of less than 5000 experience severe spontaneous bleeding. In this case, thrombocytopenia results from the body producing fewer platelets or it destroys the platelets easily, which is caused by conditions like autoimmune disease and bacterial infections (Boyer, Guihard, SBerthon and Lestienne, 2016).

 


2.Blasts cells are usually found in the bone marrow. These cells are not fully developed, and thus, they do not perform any specific function in the body. The blast cells mature in the bone marrow; they begin to perform a certain set of functions. However, if there are numerous blast cells in the bone marrow, problems like anemia and leukemia start to occur which is as a result of too many white cells left as blast cells (Petrella, Bagot, Delaunay & Muret, 2015).

In this case, the percentage of the blast in Peter’s blood plays a significant role in the finding and characterization of myelodysplastic and acute leukemia disorders (MDS). The French–American–British (FAB) taxonomy requires a percentage of a blast of no less than 30% in bone marrow (BM) or periphery blood (PB) for the determination of obstinate anemia. In this case, it requires a particular percentage of the blast in blood to sub classify Peter’s condition as obstinate anemia (Shlush, Liran & Zandi, 2014). According to Shetty, Mishra, and Hattiangady (2014), patients with <5% PB or 5–20% BM impacts are considered to have obstinate anemia, while those with more than or measure up to 5% PB or 21–29% BM blasts have obstinate anemia in transformation. On the contrary, the World Health Organization (WHO) classification does exclude the obstinate anemia in transformation class, as it diminishes as far as possible for the finding of PB blasts. Thus, in the case of Peter with numerous blasts in his blood, he is considered to have obstinate anemia, which needs immediate medical intervention (Yohe & McKenna, 2014)

 

References

Boyer, T., Guihard, SBerthon, C., ... & Roche-Lestienne, C. (2016). Tetraspanin CD81 is an adverse prognostic marker in acute myeloid leukemia. Oncotarget, 7(38), 62377.

Palmer, Rozenberg, G., ... & Machin, S. J. (2015). ICSH recommendations for the standardization of nomenclature and grading of peripheral blood cell morphological features. International journal of laboratory hematology, 37(3), 287-303.

Petrella, T., Bagot, M., Delaunay, M., ... & De Muret, A. (2015). Blastic NK-Cell Lymphomas (Agranular CD4+ CD56+ Hematodermic Neoplasms) A Review. American journal of clinical pathology, 123(5), 662-675.

Shetty, A. K., Mishra, V., Kodali, M., & Hattiangady, B. (2014). Blood brain barrier dysfunction and delayed neurological deficits in mild traumatic brain injury induced by blast shock waves. Frontiers in cellular neuroscience, 8.

Shlush, Liran I.,  & Sasan Zandi, (2014). "Identification of pre-leukemic hematopoietic stem cells in acute leukemia." Nature 506, no. 7488 : 328.

Yohe & McKenna, R. W. (2014). Langerhans cell histiocytosis in acute leukemias of ambiguous or myeloid lineage in adult patients: support for a possible clonal relationship. Modern Pathology, 27(5), 651.

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