$20 Bonus + 25% OFF
Securing Higher Grades Costing Your Pocket? Book Your Assignment at The Lowest Price Now!

Scenario Celecoxib Capsules And Glucosamine

tag 0 Download6 Pages 1,291 Words tag Add in library Click this icon and make it bookmark in your library to refer it later. GOT IT


Discuss about the with knee Pain Which Treatment Option is More Effective Celecoxib or Glucosamine?


Many people, including the esteemed athletes are often at high risks of joint problems. These problems are often associated with the very strenuous physical activities or a sudden change in physical activity that put a continuous strain on the joints. The most common problem seen in the population is the patello-femoral pain syndrome characterized by knee pain (Patrick and Keith, 2017). Knee pain might be as a result of many underlying causes a part from just the patello-femoral syndrome. The common causes are arthritis and various knee injuries. Arthritis is a disease in which the integrity of the joints of the body is affected impairing normal function and resulting in pain (Debasis, Hiroyoshi and Siba, 2011). There are many types of arthritis; osteoarthritis, rheumatoid arthritis psoriatic arthritis, juvenile arthritis and ankylosing spondylitis and almost all types can affect the knee. The pain in the knee can be relieved by a ray of drugs that function as analgesic. These drugs may have other therapeutic uses as well and among the frequently used drugs are Celecoxib and Glucosamine. These drugs have different potency levels, half-life and therapeutic windows. This research is hence set out to identify the most effective treatment option to relieve knee pain for one Mr. Kasim between the suggested drugs: Celecoxib and Glucosamine.

Celecoxib is a type of Non-Steroidal Anti-Inflammatory Drug (NSAID) (Hellen, 2014). Its brand name is Celebrex. It is often indicated in diseases like osteoarthritis, rheumatoid arthritis and ankylosing spondylitis to relieve pain and inflammation. Its mechanism of action is the blocking of the enzyme cyclo-oxygenase-2 that is involved in the formation of eicosanoids that are molecular chemicals involved in the stimulation of pain receptors and subsequent nerves stimulation to relay pain messages to the brain. This way pain receptors remain neutral despite the presence of pain at a cite, pain impulses are not generated by the nerves to relay  to the brain to register pain and as such numb the pain felt in the joint. It is contraindicated in people with asthma or other allergic disorders, stomach ulcers, liver and kidney disorders, heart and circulation problems, connective tissue disorder, and those allergic to other NSAIDs and the pregnant women.

Despite its good therapeutic effects, Celecoxib can also cause unwanted side effects that could include dizziness, abdominal pain and diarrhea, indigestion, high blood pressure, insomnia, urinary and/or chest infections, fluid retention and edema. Among the major concerns in using Celecoxib is its cardiovascular safety. At therapeutic doses Celecoxib does not inhibit cyclo-oxygenase-1 enzyme and as such proves disadvantageous as it predisposes one to myocardial infarction and stroke among many other serious cardiovascular disorders (Richard, 2013). It however has a large therapeutic window making its effective at various concentrations without causing any addition problems.

Glucosamine can also be used to relieve mild to moderate joint pain including knee osteoarthritis. It occurs naturally in the body and it is responsible for maintaining the integrity of the cartilages in the body. Its levels however decrease with age causing the breakdown of most joints. It is also artificially produced as a supplement in two main types; hydrochloride and sulfate (Keifer, 2016). The mechanism of action of glucosamine includes the reversal of the degenerative process in osteoarthritis. It is given orally with a bioavailability of 26% after first-pass metabolism. Its side effects are always mild with most developing after an overdose of the drug. They include stomach upsets, heartburn, edema, skin rash, tachycardia and headache. It is contraindicated in people with shellfish allergies and diabetes, and those who are pregnant or breastfeeding.

Despite the many good proposed advantages of using glucosamine, a limited number of studies have conducted on the safety and optimal dosage of the drug and as such it is not recommended by the Arthritis Foundation (Safran, Zachazewski and Stone, 2012) as the definitive therapeutic window is not known. It also has not been scientifically proven to have an effect on tendons, ligaments nor reverse arthritis.

Therefore, in advising Mr. Kasim on the most effective drug to use in an attempt to relieve his knee pain, I would suggest Celecoxib. This is because, for starters, Celecoxib has a wider therapeutic index meaning that its toxic concentrations are not easily arrived at and as such does not prove to be that big a risk as much as minimal toxic levels are concerned. Two, studies have proven it to be effective and safe for short term treatment of arthritis unlike glucosamine that has no prior comprehensive studies nor reports done and qualified as true as far as its safety and dosage are concerned. Also, the therapeutic effects indicated for glucosamine are speculative and not a true reflection of the drug’s capabilities. The drug is not even recommended by the Arthritis Foundation. As a result, Celecoxib proves to be more effective in the short term treatment of arthritis despite its many side effects, contraindications and cardiovascular safety concerns.


Boolean Operators     


Key words/ search terms/ phrases

Alternative words


Pathophysiology of Knee pain

Patello-femoral pain syndrome







Joint pain relievers



Causes of knee pain

I chose to use the WebMD Medical References and MedScape databases. This is because I am familiar with the use of the two databases and the search results offered by the databases are always straight to the point and very relevant to the subject in question.


For this demonstration I will use the WebMD database.


Search Mode



I first opened my browser and keyed in WebMD Medical References and clicked on the search button


A list of possible links to the WebMD page appeared

Relevance to the search word

In this browser home page I chose the first link to WebMD


The WebMD website opened.

Relevance to search word

In the WebMD page that opened I first logged in using my credentials then clicked on Health A-z tab.


A refined list of common health problems appeared. of peer-reviewed journals and scholarly articles that are significant to the search key term appeared

Search word Glucosamine

In the list I chose arthritis


Commonly asked questions on arthritis as well as articles on arthritis appeared.

Search word

In an attempt to narrow down my research, I clicked  on the types of arthritis


A list of the types of arthritis appeared in a drop down toolbox.

Tab chosen

From these I chose arthritis of the knee


A brief description under the osteoarthritis health center appeared.

Chosen tab

The search results that I obtained from the databases were very relevant to my PICO questions with the results providing direct and straight forward solutions for the questions I had set out to answer at end of the research. It was not time consuming and very good guidelines to the pharmacology of Celecoxib and glucosamine together with the pathophysiology explanation of knee pain.



Debasis, B., Hiroyoshi, M., and Siba, P. R. (2011). Arthritis: Pathophysiology, Prevention, and Therapeutics. Print.

Hellen, A. (2014). Celecoxib Capsules for Pain and Inflammation (Celebrex). Patient Platform Limited. Retrieved from Accessed on 5th April, 2017.

Keifer, D. (2016). Is Glucosamine Good for Joint Pain? WebMD Medical Reference. Retrieved from Accessed on 5th April, 2017.

Patrick, J. P., and Keith, A. S. (2017). Patello-femoral Syndrome. Medscape. Retrieved from Accessed on 5th April, 2017.

Richard, A. L. (2013). Pharmacology for Nursing Care. 901. Print.             

Safran, M.,  Zachazewski, J.,  and Stone, D. A. (2012). Instructions for Sports Medicine Patients. 2nd Edition. Elsevier Inc.429. Print.


Cite This Work

To export a reference to this article please select a referencing stye below:

My Assignment Help. (2018). Scenario Celecoxib Capsules And Glucosamine. Retrieved from

"Scenario Celecoxib Capsules And Glucosamine." My Assignment Help, 2018,

My Assignment Help (2018) Scenario Celecoxib Capsules And Glucosamine [Online]. Available from:
[Accessed 03 April 2020].

My Assignment Help. 'Scenario Celecoxib Capsules And Glucosamine' (My Assignment Help, 2018) <> accessed 03 April 2020.

My Assignment Help. Scenario Celecoxib Capsules And Glucosamine [Internet]. My Assignment Help. 2018 [cited 03 April 2020]. Available from: has become one of the leading assignment help provider in New York City and Boston. We provide top class auditing assignment help. Not only auditing, but we also cover more than 100 subjects and our writers deal with all types of assignments with utmost expertise. To make writing process faster and accurate, we have segmented our assignment experts' teams as per their expertise on writing different types of assignments. We guaranteed that students who buy our assignment online get solutions worth their investment.

Latest Healthcare Samples

HSE208: Integrated Human Physiology

Download : 0 | Pages : 4

Answer: Introduction During exercise, increased oxygen uptake by contracting skeletal muscles requires increased oxygen delivery that is achieved by increasing ventilation, cardiac output and muscle perfusion (1).  This requires the combined actions of respiratory, cardiovascular and cellular processes that deliver oxygen to contracting skeletal muscles.  The aim of this study was to investigate changes in cardiovascular (heart rate...

Read More arrow

HLTINF002 Process Reusable Medical Devices And Equipment Unit

Download : 0 | Pages : 6
  • Course Code: HLTINF002
  • University: Victoria University
  • Country: Australia

Answer: Identification and clarification of the key issues.  Discuss and provide some suggestions as to what has caused these If any instrument or piece of equipment is to be reused it requires reprocessing such as disinfection, sterilization, and or cleaning. The level of reprocessing the instruments that are reusable depends on the specific situation. There is an approach developed by Spaulding 30 years ago for patient care items and e...

Read More arrow

PHC372 Public Health Outbreak And Disater Managements

Download : 0 | Pages : 3
  • Course Code: PHC372
  • University: Saudi Electronic University
  • Country: Saudi Arabia

Answer: Introduction: Emergency and disaster planning is an almost accurate approach that involves cooperative processes from different stakeholders with the goal of minimizing the spread of disaster outbreak. Failure to plan is risky as it places the lives of other people at risk and may increase the costs of managing and eradicating disasters. Actions plans are needed not only for managing the disaster, but also for continuity of life as so...

Read More arrow

HSN701 Principles Of Nutrition T3 2018

Download : 0 | Pages : 11

Answer: Introduction Long poly unsaturated fatty acids (LCPs) such as arachidonic acid (AA) and docosahexaenoic acid (DHA) have been documented to be advantageous for the growth and development of an infant. (Scholtz, Colombo and Carlson 2013). This report focuses the weight of scientific evidence available on the benefits associated with infant formulas supplemented with LCPs, through an extensive electronic literature search using key words...

Read More arrow

HSA405 Healthcare Policy And Law

Download : 0 | Pages : 11

Answer: Introduction The healthcare organization has experienced a decrease in the quality of patient care over the past few months.  The Chief Executive Officer has requested an internal analysis based on an increased number of patient complaints.  The quality of patient care provided by healthcare organizations and providers is the cornerstone of any successful healthcare organizations. It has been assumed that the patient compla...

Read More arrow

Save Time & improve Grades

Just share your requirements and get customized solutions on time.

We will use e-mail only for:

arrow Communication regarding your orders

arrow To send you invoices, and other billing info

arrow To provide you with information of offers and other benefits




Overall Rating



Our Amazing Features


On Time Delivery

Our writers make sure that all orders are submitted, prior to the deadline.


Plagiarism Free Work

Using reliable plagiarism detection software, only provide customized 100 percent original papers.


24 X 7 Live Help

Feel free to contact our assignment writing services any time via phone, email or live chat.


Services For All Subjects

Our writers can provide you professional writing assistance on any subject at any level.


Best Price Guarantee

Our best price guarantee ensures that the features we offer cannot be matched by any of the competitors.

Our Experts

Assignment writing guide
student rating student rating student rating student rating student rating 5/5

203 Order Completed

97% Response Time

Richard Alpert

PhD in Psychology

London, United Kingdom

Hire Me
Assignment writing guide
student rating student rating student rating student rating student rating 5/5

610 Order Completed

100% Response Time

Cheryl Zhao

PhD in Statistics

Singapore, Singapore

Hire Me
Assignment writing guide
student rating student rating student rating student rating student rating 5/5

265 Order Completed

97% Response Time

Ken Campbell

MSc in Electrical Engineering

Wellington, New Zealand

Hire Me
Assignment writing guide
student rating student rating student rating student rating student rating 4/5

1309 Order Completed

100% Response Time

Gemmie Chen

MSc in Nursing

Singapore, Singapore

Hire Me

FREE Tools


Plagiarism Checker

Get all your documents checked for plagiarism or duplicacy with us.


Essay Typer

Get different kinds of essays typed in minutes with clicks.


GPA Calculator

Calculate your semester grades and cumulative GPa with our GPA Calculator.


Chemical Equation Balancer

Balance any chemical equation in minutes just by entering the formula.


Word Counter & Page Calculator

Calculate the number of words and number of pages of all your academic documents.

Refer Just 5 Friends to Earn More than $2000

Check your estimated earning as per your ability




Your Approx Earning

Live Review

Our Mission Client Satisfaction

The assignment was return to me on time has to make corrections and adjustment myself but still made a good grade. thanks


User Id: 392946 - 02 Apr 2020


student rating student rating student rating student rating student rating

OMG this was totally better than expected and worth every penny!!! I suck at math so i\'m excited to see my grade!


User Id: 394019 - 02 Apr 2020


student rating student rating student rating student rating student rating

Very happy with work provided by My assignment Excellent work. Always with in deadline.


User Id: 228464 - 02 Apr 2020


student rating student rating student rating student rating student rating

Haven\'t get result yet but already feel like a great piece of writing, no disappoint.


User Id: 329158 - 02 Apr 2020


student rating student rating student rating student rating student rating
callback request mobile
Have any Query?