Hemostasis is stopping the bleed or the hemorrage. The stopping of the flow of blood in the blood vessels or in the organ of body is known as Hemostasis. This is arresting of bleeding which might include vasoconstriction (closing of the blood vessels temporarily) or stoping of blood by abnormal obstruction or by surgical methods or coagulation. The surgical means it includes ligation. There is also brain hemorrage which is a bleeding in the brain. The main cause of brain hemorrage causes because of high blood pressure or because of abnormally weak or some dilated blood vessels that has leakage, or may be because of drug abuse or because of trauma. There are many people who can experience some brain hemorrage that have many symptoms as because they have stroke as well as develop weakness from only one side of their body.
The Hemostasis mainly includes three different steps that mainly occurs in some rapid sequence.
1. Vascular Spasm or vasoconstriction- The intact blood vessels are considered as central to the moderating of the tendency of blood clotting. All endothelial cells that are intact in the blood vessels mainly helps to prevent all the platelet aggregation as well as stops the process of coagulation that cascade with prostacyclin or with nitric oxide. When there is endothelial injury, then the endothelial cells prevents the secretion of the coagulation process as well as aggregation inhibitors and thus secrete the factor of von Willebrand that helps to cause platelet adherence because of initial occurrence of the clot. The Vascular Spasm mainly occurs during the Hemostasis process as reflexive contraction that mainly helps to decrease the flow of blood in that particular area.
2. Formation of the platelet-
The platelets mainly creates platelet pug that helps to form direct blood vessels that are mainly ruptured. Within 20 second of the injury of the blood vessel coagulation is generally initiated. This takes about 60 seconds until first beginning of fibrin strands for interspersing the wound. The plug platelet is mainly formed by the process of fibrin.
The clotting of blood in case of the skin injury is mainly caused by due to exposure in the air but because of the platelets adhering and is mainly activated because of the collagen that are present in the blood vessels of endothelium.
3. Clotting of blood or Coagulation-
The platelet plug is not enough to stop the bleeding and in the third stages in the beginning of Hemostasis the formation of the blood clotting is done. The platelet mainly contains secretory granules. When the platelets sticks to the proteins in the walls of vessels, the platelets de-granulate and as a result of that it releases the products that includes ADP as well as A2 in the blood vessel. The ADP is adenosine diphosphate and the A2 activates in other platelets. When the blood vessels gets damaged, the vessels as well as platelets gets simulated as because they release all the substance that are called prothrombin activator.
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