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Molecular pharmacology denotes - the scientific study of bio-physical and bio-chemical characteristics of drugs at a molecular level, along with their interaction with and effects on biological macromolecules, cell structures and processes.
More specifically, the study explains drug action mechanisms like their interaction with enzymes, receptors, and other macromolecules in cells.
Regarded as a fascinating field of study, the course assists students in comprehending the way new therapeutic drugs are designed and assessed.
Of course, students must also use whatever they’ve learned and craft well-written and extensively researched papers on the college/university chosen assignment topic. Moreover, they must finish the task within a tight deadline.
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As you already gathered from the above section – “Molecular Pharmacology reveals the way molecules intermix with cellular on both molecular and sub-molecular levels to produce the desired effect.”
Students who take up the study of molecular pharmacology have to deal with many complex (yet fascinating) chapters, namely –
Students must understand all molecular pharmacology principles and implement these concepts when studying drug action.
Furthermore, in recent times, research pertaining to Molecular Pharmacology has advanced considerably. Appreciative advancements are seen in the research field of GPCRs – (G-protein-coupled receptors)!
GPCRs compile a large family of membrane proteins mediating several cellular responses to various external stimuli. Unfortunately, previous research on G-protein-coupled receptors was hindered due to insufficient high-resolution structural data and information. But recent breakthroughs in Cryo-EM – (Cryo-Electron Microscopy) have enabled its exponents/scientists to acquire GPCRs’ comprehensive structures in both active and inactive states.
These positive outcomes have revolutionised the understanding of how such proteins function and help develop several new drugs oriented to GPCRs.
Besides G-protein-coupled receptors – another on-going area of research in molecular pharmacology is in transcription factors (namely proteins that regulate gene expressions by binding them to particular sequences of DNA)!
The progress is positive so far and has resulted in a better understanding of the function and structure of transcription factors. And the knowledge has been fruitful in developing fresh drugs targeting specific transcription factors resulting in cancer and other disease development.
Finally, molecular drug development is another research field allowing scientists to utilise vivid techniques for designing and synthesising effective new drugs targeting particular proteins and pathways in disease.
So, it is safe to establish that the study of molecular pharmacology involves a sound knowledge of medicinal chemistry, pharmacology, biology, and biophysics along with awareness of all these on-going researches and their breakthroughs.
Unfortunately, many students struggle to come to grips with its complex fields of study and its on-going research work. Some even find difficulty in doing extensive research work simply as they don’t know which web source is reliable! Therefore, they fail to produce quality research assignments within the deadline!
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Discuss about the Article for Molecular Cell Biology for A Review.
Review 1
The diagrammatic explanation of role played by Nitric oxide and cGMPA in muscle activation worked well in this presentation. I liked the way the whole mechanism was presented by stating all the mechanism step by step and systematically. I think the topic was well organized starting from the discovery of nitric oxide by three different scientists independently with the famous Furschgott Sandwich Experiment and then moving to explaining the main mechanism behind muscle relaxation. It clearly states how each scientist contributed to the understanding of its role. I learned the relation between NO and cGMP and how its activation leads to muscle reaction. However I would like to know more about each role of Calcium ions as this part was missing in the presentation. The physiological role and effect on each system were clearly stated in the presentation starting from L-arginine to formation cGMP and then its role in the phosphorylation of protein kinase G. I wished the writer could have presented a more clear illustrative diagram in the slide for endothelial role. Nitric Oxide synthase can target protein in proximity due to the phosphorylation of protein kinase G[1]. Myosin phosphatase plays the role in smooth muscle relaxation and it also explained another role like platelet inhibition and change in gene expression[2]. However, the presentation did not drift away from its purpose and concentrated mainly on an endothelial function related to NO. The biological mechanism of NO and cGMP was explained effectively in endothelial and smooth muscle cells. Reporting future research about NO was also a good way to end the presentations, however I would like to have more clarification regarding role of Yervoy as NSAID drugs.
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Yes. Our Molecular Pharmacology Assignment Helper in the UK offers tutoring and guidance on all course chapters and their topics.
Here’s a Sneak-Peek
Topics include – Molecular biology techniques, PCR – Polymerase Chain Reaction, Next-Generation Sequencing, RNA/DNA Microarrays, Gel Electrophoresis and Western Blotting, And Pharmacogenomics/Pharmacogenetics!
Topics include – CAR-T Cell Cancer Therapy, Monoclonal Antibody Therapy, and Recombinant Protein Therapeutics.
Topics include – Gene Editing Therapy, Gene Replacement Therapy, Gene Slicing Therapy, Therapeutic Applications of Epigenetics (Or DNA Methyltransferase)
Topics include – Tissue Engineering And Bio-Printing Utilising a material derived from Stem Cell, Oct & Sox Transcription Regulation, and RNASeq – Stem Cell-Derived Organoids.
Besides these research paper topics, we also provide tutoring and guidance on many other critical studies of Molecular Pharmacology.
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