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Medical Cytology is a specialized branch of pathology that is concerned with the diagnosis of diseases and symptoms in the patients. It involves an examination of tissue samples and the study of body fluids and aspirated materials like blood etc. The examination is conducted at a cellular level using microscopes.
Cytology deals with the microscopic study of the cell samples collected from a particular area of the body. On the other hand, biopsy refers to the surgical removal of a tissue sample to determine the state of the disease like a lesion.
There are two different types of cytology, namely Exfoliative cytology and Aspiration Cytology. Exfoliative cytology refers to the cell samples that exfoliate from superficial, deep serosal or mucosal surfaces and involve urinary cytology, body fluid cytology etc. Aspiration cytology deals with fine needles that help in aspirating cellular materials for proper diagnosis. Aspiration has been used on palpable and non-palpable lesions.
Cytology samples can be collected from any part of the body. Depending upon the nature of cytology, Exfoliative or Aspiration, you have gynaecological, urine, sputum, pleural, pericardial, mucosa samples, etc. Moreover, you can also have lesion samples, peritoneal, cerebrospinal fluid samples.
Cytology is not the same as Pap smear. To enhance the diagnostic reliability of the Pap smears, liquid-based cervical cytology was developed, which helps in rinsing cervical cells in preservatives so that obscuring materials like blood can be separated. Due to inadequate slide preparation, traditional pap smears used to provide false-positive and false-negative results.
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