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CEPI0913 Introduction to Nanotechnology

1. What is the tunneling current and its role in an STM?

2. How does electron microscopy differ from optical microscopy?

3. How can nanoparticles be stabilized to prevent their aggregation?

4. Why coat nanoparticles or quantum dots with other materials?  Give a few examples.

5. What is meant by bandgap in quantum dots?  How does the bandgap affect the optical properties of quantum dots?  How can bandgap be tailored?

6. Some areas of nanotechnology evolved from microtechnology. Give an example.  Will there be a picotechnology?

7. Why are some  monolayers described as self-assembled?  Are there ‘force assembled’ monolayers?
  1. Gravity forces help nanomaterials in self-assembly processes.
    2.  Many nanostructures are interesting because they minimize the effects of surfaces
3. Nanostructures are so small that phenomena resulting from the wave properties of light are not very important.
4. Nanostructures are comparable in size to many biological structures in the cell.
5. Bottom-up fabrication methods are based on technology currently used in the semiconductor/microelectronics industry.
6. Lithography is done exclusively with UV light.
7. Nanoparticles are almost always highly toxic.
8. Carbon nanotubes are fragile materials and must be handled very carefully.
9. Carbon nanotubes are used in transistors as electrical insulators. 
10. Light-emitting diodes are typically made out of silicon.
11. Most solar cells are made from silicon.
12. The hotter an object gets, the shorter wavelength of radiation it emits.
13. Using  a fan to keep an object cool is an example of radiative heat transfer.
14. Silicon with many impurities is a good electrical insulator.
15. Generally, if a material is a good thermal conductor, it is a poor electrical conductor.
16.  Most solid materials are amorphous.  The crystalline state of materials is relatively rare.
17. Fluid flow at the microscale is almost invariably turbulent.
a) Basically, how does it work?
b) Why aren’t antibodies needed to target the particles to the tumor?
c) Iron nanoparticles: What are the issues and how is it dealt with?
d) By what figure of merit or metric do they say their product is about 16x more effective than previous tries?
e) How do they measure the increase in tumor temperature?
f) How much can you inject into a typical lab rat before killing 50% of them?
3. Briefly, how were the CNTs functionalized?
4. How do the functionalized CNTs get into the cell in the first place?
5. What is the relevance of cytotoxicity here? And how is it assessed?
6. How do they know the CNTs got into the mitochondria?
7. About how big are these CNT complexes?
8. Okay, if we can deliver functionalized CNTs to the mitochondria, what are the therapeutic applications.
9. Suppose we want to add some ‘cargo’ to the CNT. How?
Explain TGA, Kaiser test, and TEM as used here.

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