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23787 Health Technology Assessment

tag 0 Download 13 Pages / 3,018 Words tag 26-11-2020


NOTE: All costs calculated should be presented to two decimal places.

Mark Allocation for Part Four: (as follows):

Correctly identifies the cost elements


Allocates costs correctly to each test outcome for current test


Allocates costs correctly to each test outcome for new test


Part Five: Cost-utility analysis

You should now have the following information:

  • Accuracy of the current and new cervical screening tests
  • A decision tree that reflects the possible outcomes of both tests
  • An estimate of the QALYs gains for each alternative
  • An estimate of the resource use (cost) of each alternative

The final information that you need to complete the analysis is the prevalence of cervical cancer in this population. In this example, we are screening women 30 years of age; the prevalence of cervical cancer in this cohort is 1 in 1,000 or (0.001)

  1. Complete Table 3: Model parameters using the information from Part One to Part Four.

Table 3: Model Parameters

Parameter description

Current Test

New Test

Prevalence of cervical cancer



Sensitivity of test



Specificity of test



Cost – True Positive



Cost – False Positive



Cost – True Negative



Cost – False negative



QALYs – True Positive



QALYs – False Positive



QALYs – True Negative



QALYs – False negative



  1. B) You now need to combine this information into your decision tree to determine the cost-effectiveness of the new test relative to the current test. Provide your answer as an incremental cost-effectiveness ratio (ICER; i.e. cost/QALY gained). Provide the diagram of your populated decision tree at this stage.
  • Hint: Remember that you need to calculate the expected value (costs and QALYs) of each alternative before you can estimate the cost-effectiveness. It is easier to calculate the expected value if you start at the end of the tree, rather than the beginning (i.e. you need to roll-back the decision tree – see lecture notes for example)

Mark Allocation for Part Five (B): (as follows):

Correctly allocates the parameter values to the decision tree


Correctly estimates the expected value of each strategy


Correctly estimates and presents the ICER


Provides a diagram of the decision tree


  1. C) If the decision maker has set an explicit threshold of $50,000 / QALY gained, would you say the new test is cost-effective?Explain your answer.

Part 6: Sensitivity Analysis

The decision maker would like you to determine the cost-effectiveness of the new test in a population of women without a family history of cervical cancer. In this high-risk cohort of women, the prevalence of cervical cancer is 2 in 100 (0.02).

  1. A) Calculate the ICER of the new test relative to the current test in this high-risk population of women.
  2. B) Why do you think the cost-effectiveness of the new test is sensitive to the prevalent risk of cervical cancer in the population?
  3. C) In the original model (hint: assuming prevalence = 0.001), we assumed a 20 min GP appointment costs $35. However, an audit of general practices conducting the new test shows that 90% of GPs charge patients a double appointment (2 x 20mins). How does this change your ICER? Explain your answer.

Mark Allocation for Part Six (C): 4 marks (as follows):

Correctly allocates the change in cost in the decision tree


Correctly estimates and presents the ICER


Provides a clear explanation of the result


  1. D) Is the model sensitive to any other parameters? Please justify your answer.
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Total 13 pages

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My Assignment Help (2020) Health Technology Assessment [Online]. Available from:
[Accessed 18 August 2022].

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