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23787 Health Technology Assessment

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  • Course Code: 23787
  • University: University Of Technology Sydney
  • Country: Australia

Question:

NOTE: All costs calculated should be presented to two decimal places.

Mark Allocation for Part Four: (as follows):

Correctly identifies the cost elements

 

Allocates costs correctly to each test outcome for current test

 

Allocates costs correctly to each test outcome for new test

 

Part Five: Cost-utility analysis

You should now have the following information:

  • Accuracy of the current and new cervical screening tests
  • A decision tree that reflects the possible outcomes of both tests
  • An estimate of the QALYs gains for each alternative
  • An estimate of the resource use (cost) of each alternative

The final information that you need to complete the analysis is the prevalence of cervical cancer in this population. In this example, we are screening women 30 years of age; the prevalence of cervical cancer in this cohort is 1 in 1,000 or (0.001)

  1. Complete Table 3: Model parameters using the information from Part One to Part Four.

Table 3: Model Parameters

Parameter description

Current Test

New Test

Prevalence of cervical cancer

0.001

0.001

Sensitivity of test

0.74

 

Specificity of test

0.94

 

Cost – True Positive

 

 

Cost – False Positive

 

 

Cost – True Negative

 

 

Cost – False negative

 

 

QALYs – True Positive

 

 

QALYs – False Positive

 

 

QALYs – True Negative

 

 

QALYs – False negative

 

 

  1. B) You now need to combine this information into your decision tree to determine the cost-effectiveness of the new test relative to the current test. Provide your answer as an incremental cost-effectiveness ratio (ICER; i.e. cost/QALY gained). Provide the diagram of your populated decision tree at this stage.
  • Hint: Remember that you need to calculate the expected value (costs and QALYs) of each alternative before you can estimate the cost-effectiveness. It is easier to calculate the expected value if you start at the end of the tree, rather than the beginning (i.e. you need to roll-back the decision tree – see lecture notes for example)

Mark Allocation for Part Five (B): (as follows):

Correctly allocates the parameter values to the decision tree

 

Correctly estimates the expected value of each strategy

 

Correctly estimates and presents the ICER

 

Provides a diagram of the decision tree

 

  1. C) If the decision maker has set an explicit threshold of $50,000 / QALY gained, would you say the new test is cost-effective?Explain your answer.

Part 6: Sensitivity Analysis

The decision maker would like you to determine the cost-effectiveness of the new test in a population of women without a family history of cervical cancer. In this high-risk cohort of women, the prevalence of cervical cancer is 2 in 100 (0.02).

  1. A) Calculate the ICER of the new test relative to the current test in this high-risk population of women.
  2. B) Why do you think the cost-effectiveness of the new test is sensitive to the prevalent risk of cervical cancer in the population?
  3. C) In the original model (hint: assuming prevalence = 0.001), we assumed a 20 min GP appointment costs $35. However, an audit of general practices conducting the new test shows that 90% of GPs charge patients a double appointment (2 x 20mins). How does this change your ICER? Explain your answer.

Mark Allocation for Part Six (C): 4 marks (as follows):

Correctly allocates the change in cost in the decision tree

 

Correctly estimates and presents the ICER

 

Provides a clear explanation of the result

 

  1. D) Is the model sensitive to any other parameters? Please justify your answer.
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My Assignment Help (2020) Health Technology Assessment [Online]. Available from: https://myassignmenthelp.com/free-samples/23787-health-technology-assessment/musculoskeletal-physical-examination-e-book.html
[Accessed 27 January 2021].

My Assignment Help. 'Health Technology Assessment' (My Assignment Help, 2020) <https://myassignmenthelp.com/free-samples/23787-health-technology-assessment/musculoskeletal-physical-examination-e-book.html> accessed 27 January 2021.

My Assignment Help. Health Technology Assessment [Internet]. My Assignment Help. 2020 [cited 27 January 2021]. Available from: https://myassignmenthelp.com/free-samples/23787-health-technology-assessment/musculoskeletal-physical-examination-e-book.html.


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