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BIOL2010 Biochemistry

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Question 

Proteopathies

Protein structure is directly associated with protein function. Proteopathies are a broad class of diseases where abnormalities in protein structure result in abnormal configuration, protein misfolding or toxicity. These diseases are a major burden of human and agricultural animal health and result in multiple debilitating or fatal diseased states. A list of proteopathic diseases is located below. For this assignment, you will choose one of these diseases and assess several criteria in the form of a mini-review article suitable for publication in a scientific journal.

Human Prion Diseases:
  • Creutzfeldt-Jakob Disease (CJD)
  • Cystic Fibrosis
  • Alzheimer's disease
  • Sickle cell disease
Animal Prion Diseases
  • Bovine Spongiform Encephalopathy (BSE)
  • Chronic Wasting Disease (CWD)
  • Feline spongiform encephalopathy
  • Scrapie
The remainder of the word count (900 words) should make up the body of your review. This should include the following information:

a. A description of the molecular events that cause your protein of interest to adopt an abnormal state.
b. Explain how abnormal protein structure leads to disease and discuss current treatments.
c. Finish your review with a conclusion that offers the reader a take-home message of your review.
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