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1 Discuss the mechanism of naloxone in reversing overdose. Provide commentary around the historical emergence and challenges of naloxone as a “take home” medication to those with opiate use disorders.

2 Is take home naloxone effective? Provide a brief literature review examining the efficacy of take home naloxone programs.

3 Recent literature suggests that others are present in up to 70% of prescription opiate overdoses resulting in death. Is there a role for take home naloxone in those who use/abuse prescription opiates? 2000 words essay must be in apa 6th style. please read and follow the attached document for marking guide.

What is Naloxone?

Naloxone is a narcoticanalgesic antagonist, C19H21NO4, used in thereversal of acutenarcoticanalgesicrespiratorydepression. The medicine brings better results when administered at an overdose to block the high concentration of heroin or opioids in the body of a patient. The medication is most effective when administered through injections since it will prevent the usagewhen administered orally as a tablet is not that effective until it is crushed for injection. The intended result of reversal having the naloxone process is high; the take home naloxone is useful as it reduces the opioid and the heroin overdose in people who are infected. To minimize the deaths that may occur due to the wrong usage or any other thing that may cause death it needs to be handled through giving training to the patients and also to people taking care of them. Knowledge about the medicine is very critical to avoid misuse. The patients should have a role of following the given prescriptions since lack of instructions follow up from a doctor to a patient it may lead to dangerous conditions or even death.

Naloxone is a medicine mainly used to block the consequences of opiates when overdose, this induces the respiratory diseases that can lead to other problems or even death(Wheeler, Jones, Gilbert, & Davidson, 2015). Argues that opiates prevention systems of giving naloxone to persons in the US. 

Intended results of reversal about the dose processarehigh; the take-home naloxone is useful as it reduces the opioid overdose in people that may be infected in them. Naloxone is a safe treatment or dose that is believed not to have any harm when given in representative doses to opiates overdosedpatients it is also not involving selection and better than others in the same category opioid receptor antagonists; this works by reversing diseases for the complex of the nerve tissue which have control of all the body activities and breathing caused by opioids. (Faul et al.,2015).Argues about the great difference in the dose process, this will be achieved throughthe urgent medical experts  and the loadto protect the safety and improving the health of the communities.

In hospitals the medication is applying in low doses which is later continuously measured and adjusted, the balance of drug dosage to make the best change couse of action of opioid-induced breathing issues for a period of time trying to make the danger of removal low that may include restlessness, nausea and also a rapid heartbeats, to avoid all this little doses every few sixty seconds until the desired condition is attained.( Strang et al., 2016).Highlights that naloxone that is given without using the injection results of candidate routes for failure of injecting naloxone for opiates change of drug and liquor addiction.

Intended Results of Naloxone

In history,Narcan is a better as compared to other mu-opioid blockers used only by health trainedindividuals in hospitals. Formulations having the purpose of many other routes of administration are currently under development. The medicine is not in most cases given orally due to coveringfirst-bass chemical reaction in the liver that provides much of not involving in physical activities, in spite of the fact that the ability to produce needed results has been reportedto be between a dose of one thousand three thousandmilligram and the period of the thing done issaid to be between six- twenty fourhours. At great level doses of twomilligram or kilogram, patients only experience related to behavior conditions related to the disease such as losing balance, sweating, nausea, without much demanding side effects. Sufficiently greatchanges in blood pressure when the heart itself is contracting and breathing frequency in the absence of a considerable shift in connection were solely seen in good health participants when specified with naloxone at amount of two–four milligram or kilogram. Scientists discovered that several victims who encountered with possible naloxone signs, there no existing connection to treatment offered to them. On the condition being protected and success of naloxone is when given by health providers. Naloxone possess some familiar undesired outcomes which do not have capability purpose to misuse, and is able to be obtained at an understandable average cost, in spite of the fact that there has been recent be about over cost increases. Health professionalshavebegunto perform a procedure in the laboratory with new skills to give naloxone at a fast speed and safely under not related to hospital work order which gave the dose in low quantities to the patients.(Davis & Carr, 2015).Argues about the increaseof naloxone overdose reversal and also the drug and alcohol independence. 

The take homenaloxonemedicine is more usefulsince it when given the small doses in the hospital the other ones can be done at home and eliminate the type if problems that may be raised by opioids, for example, the depression for the nervous and also the respiratory system like the pulmonary edema. It reduces the number of people that may be infected in the opioids. (Giglio, Li & DiMaggio, 2015).Argues about the success of a person who is present but do not take part naloxone process and overdose education performance.

The intended result of change about the naloxone success beyond people be great, possessbe observered at seventy five– one hundred % having that to be a high percentage and to conclusion about the efficacy of the take-home naloxone performances are looked attentively to be very useful for reducing opioid-overdose mortality in patients.(McAuley, Aucott& Matheson, 2015).Argues about inquiring into serving possibility of naloxone: a methodical examination and illustrative quantitative statistical inspection of taking place of residence naloxone performances intended to be given to opioid patients.

Naloxone Dosing and Administration

It is best for the patients to be given the take – home naloxone medicine it will benot only helpful to treat the opioids but also kind enough to avoid one involving themselves in the drugs morality, for example, the heroine with a high addiction to the drugs.(Hill, 2015).Argues about avoiding opioid extensive dose in Sweden as a cost-effectiveness structure of naloxone giving out.

Naloxone be able toalsobe cast off on children that maybe uncovered to inside the uterine drug given to mothers throughgiving birth; the mother might be a opioids patient that’s why the medication is administered simultaneously to the little infant. Nevertheless, there is inadequate informationfor the use of naloxone to decrease actions related to heart and lungs and organic disorders of the nerves and the nervous system in these children. Children exposed to high concentrations of opiates during the period of being pregnant may haveminimum tissue injury (traumatic brain or traumatic spinal injury) in the setting of birth asphyxia which the body is deprived from oxygen. The naloxone medication is too cost – useful to a point that many opiate patients can afford it. (Barra et al 2018).Argues about the cost success of naloxone performances for the care of opiateand addictive narcoticoverdose in the thoroughfare. 

Without being affected by the extended - positionuse of naloxone to reverse the signs of opioid excessive dose, accurate dosing remains public disagreement, with different amount of dosesdoses required over time and by medical professionals to the patients. Mainly, naloxone is only give good performance in changing an excessive dose of drug if given ahead of dangerous dose signs that origindeathare indicated in a patient. Medical specialized trainees’ respondents and serious emergency departments have and are having knowledge of naloxone. Nevertheless, it is frequently the instance that the amenity providers comebehindtime to restore to life of overdose victims though the naloxone is more effective when given as a take- home medication. The success of naloxone is completely time dependent, that is if the medication is given before death symptoms or after the show up of the death symptoms. Death occurs inside a time period of one to three hours after an overdoseis administered. Therefore, naloxone is only effective when is applied when the death symptoms have not shown up since it will hard to manage it when the death symptoms have shown there are high chances that the patient may not survive, that would be a disadvantage due to population reduction. The success of the take home medicine is more efficient only to some circumstances that may arise in the patient’s conditions but to conclude the whole thing if the take home medicine is useful as it treats the patients if there is no misuse of the medication(Lee& Ripley,2017). Arguesabout the examining the effectiveness of naloxone in opioid overdose in hospitals or at home.

Importance of Training Patients on Naloxone Usage

Trainingis explained as a better part of take-home naloxone administrationprogrammed that can achieve a desired results increase participant’s knowledge, confidence,and specialised skills in managing an opiates patients.(Rando et al., 2015). Argues about lying within the nose naloxone operation by police first to provide assistance is related with drop of opioid excessive level of drug deaths in prisons. Training can be offered to current and former opioid users, cares and staff in occurring contact with users to know how they are going on with their take home drugs to avoid misuse. It should be done to each setting, having in mind a personneeds and accessible capital. Three degree of teachingare naratted: short, leveland progress. Thetest of excess level of drugs interconnectedknowledge and capability ahead and afterwardstraining is needed a lot to avoid the deaths associated with the opioids. In the recent studies of reaction(Bird et al.,2016), highlights about the success programmed intended to be lessen opioidinterconnected deaths.

When naloxone is not successful in changing an excessive dose of drug if given ahead of excessive dose signs that lead to death is indicated, the patient is likely to die to lack of fast responding to help the patient in whatever way.The opiates and heroin contribute more to medicine deaths: though opiate has a smaller part of the complete utilization of unlawful medicine within the world, however adds  eighty percent total drug excessive dose of drug deaths.(Schneir et al.,2017).Argues about the near death: the disclosure of  current opiates category as per the impersonal detection of poisons.

Opiates are steadily compromise in the awareness to fatalities whilethe significant injure of illegal drug put to wrong use they are encouraged and advised to stop the drug abuse to reduce the deaths occurring.(Mueller., 2015).Highlights analysis of opioid excessive use to stop and naloxone prescriptions and the suggestion for interpreting community scheduling into impersonal application.

Many of the opiate excessive use of drug deaths besides it require the operating use of more kinds of drugs for example alcohol; however, it is the breathing issues caused by narcotic that is the primary system of death. The patients are trained and impacted knowledge to avoid the misuse of the drugs and not to use more overdose as required. (Patrick et al., 2016).Argues about the execution of instruction drug observing schedule similar with cutback in opioid associated death rates. Jails have an extremely force, but tangled, connection with the heroin and opiate applying action for so many of their convicts and constitute a frequently failed to see possible involvement chance, in spite of their main unlawful fairness function. 

Meanwhile this goes on over groups according to unlike unlawful fairness reactions to the drug wrong use trouble, detention centers contain a remarkable close attention of the people at chance of afterwardsheroin overdoseleading to death, naloxone medication cannot be offered to prisoners as there may be a lot of misuse in the medicine. (Kestler et al., 2017).Argues about the elements affiliated with involvement in a crisis department form take home naloxone program for possibility of opioid users. If home taking medication is risky due to misuse what about being issued to prisoners? It will more than dangerous since the inmates can do anything what so ever to see themselves not being in prison that can be death or anything else.

Since naloxone is not available over-the-counter and is only obtainable throughprescription from a doctor, it is essential to work with a medical professional who can prescribe the drug for the program to avoid using without any prescription to lessen the number of demises that may occur inside the program. Arrangements can be made to provide protection for the prescriber of naloxone and to third-party administrators (the person who revive a person with an overdose of the drug) to make sure there is no any misuse on the drugs taken by the opiate overdosed patients.(Eggleston, Clark&Marraffa, 2017)Argues that condition lawful changes to uplift naloxone distribution. The role the opiate overdose patients when they take the medication home are to ensure that they take according to the prescriptions given.


When the medicine is received in an overdose is likely that it would cure the heroin and the opioids addiction’s. The dose is quickly and safely under non – hospital conditions, the drug is not valid when taken orally as a tablet yet if the pill is squeezed for injection the medication closes any possible more it also increases the blood streams in a person.Naloxone possess a small number of familiar unfavorable effects, not any possible for misuse, and is obtainable at a fairly small cost, though there has been current worryover cost rise. The medicalexpertise’s began to perform a specific procedure with current abilities to control naloxone rapidly and is likely not to cause any harm directly below not related health center surroundings which gave the medication in low quantities to the patients. The take home naloxone medicine is more useful since it when given the small doses inthe hospital the other ones can be done at home and eliminate the type if problems that may be raised by opioids. It reduces the number of people that may be infected in the opiates. The intended result of reversal about the naloxone management beyond people is excessive, experiencebeen given an account of seventy five–one hundred percent having that to be a high percentage. 


Bird, S. M., McAuley, A., Perry, S., & Hunter, C. (2016).The effectiveness of Scotland's National Naloxone Programme for reducing opioid?related deaths: a before (2006–10) versus after (2011–13) comparison. Addiction, 111(5), 883-891.

Barra, M., Direnzo, G. F., Patruno, F. V., Patti, M., Rodoquino, G., Rossi, E., ...&Badiani, A. (2018). The cost-effectiveness of naloxone programs for the treatment of heroin overdose in the ‘street’: a 2-years data collection by the Street Unit of the Villa Maraini Foundation. Heroin Addiction and Related Clinical Problems.

Davis, C. S., & Carr, D. (2015).Legal changes to increase access to naloxone for opioid overdose reversal in the United States.Drug and alcohol dependence, 157, 112-120.

Eggleston, W., Clark, K. H., &Marraffa, J. M. (2017).Loperamide abuse associated with cardiac dysrhythmia and death. Annals of emergency medicine, 69(1), 83-86.Davis, C., & Carr, D. (2017).State legal innovations to encourage naloxone dispensing.Journal of the American Pharmacists Association, 57(2), S180-S184.

Faul, M., Dailey, M. W., Sugerman, D. E., Sasser, S. M., Levy, B., &Paulozzi, L. J. (2015).The disparity in naloxone administration by emergency medical service providers and the burden of in US rural communities. American journal of public health, 105(S3), e26-e32.

Giglio, R. E., Li, G., & DiMaggio, C. J. (2015).The effectiveness of bystander naloxone administration and overdose education programs: a meta-analysis. Injury epidemiology, 2(1), 10.

Hill, P. (2015). Preventing opioid overdose in Sweden: A cost-effectiveness analysis of naloxone distribution: A study protocol.

Kestler, A., Buxton, J., Meckling, G., Giesler, A., Lee, M., Fuller, K., ...&Scheuermeyer, F. (2017). Factors associated with participation in an emergency department–based take-home naloxone program for at-risk opioid users. Annals of emergency medicine, 69(3), 340-346.

Lee, R., & Ripley, N. (2017).Examining the effectiveness of naloxone on opioid overdose: A structured review.

McAuley, A., Aucott, L., & Matheson, C. (2015).Exploring the life-saving potential of naloxone: a systematic review and descriptive meta-analysis of taking home naloxone (THN) programmes for opioid users.Inter

national Journal of Drug Policy, 26(12), 1183-1188.

Mueller, S. R., Walley, A. Y., Calcaterra, S. L., Glanz, J. M., & Binswanger, I. A. (2015). A review of opioid overdose prevention and naloxone prescribing: implications for translating community programming into clinical practice. Substance abuse, 36(2), 240-253.

Patrick, S. W., Fry, C. E., Jones, T. F., &Buntin, M. B. (2016). Implementation of prescription drug monitoring programs associated with reductions in opioid-related death rates. Health Affairs, 35(7), 1324-1332.

Rando, J., Broering, D., Olson, J. E., Marco, C., & Evans, S. B. (2015). Intranasal naloxone administration by police first responders is associated with decreased opioid overdose deaths. The American journal of emergency medicine, 33(9), 1201-1204.

Schneir, A., Metushi, I. G., Sloane, C., Benaron, D. J., & Fitzgerald, R. L. (2017). Near death from a novel synthetic opioid labeled U-47700: emergence of a new opioid class. Clinical toxicology, 55(1), 51-54.

Strang, J., McDonald, R., Alqurshi, A., Royall, P., Taylor, D., & Forbes, B. (2016). Naloxone without the needle− systematic review of candidate routes for non-injectable naloxone for opioid overdose reversal. Drug and alcohol dependence, 163, 16-23.

Wheeler, E., Jones, T. S., Gilbert, M. K., & Davidson, P. J. (2015). Opioid overdose prevention programs providing naloxone to laypersons-United States, 2014. MMWR.Morbidity and mortality weekly report, 64(23), 631-635.

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